Leonardo DiCaprio Dr. Randall Mindy Jennifer Lawrence Kate Dibiasky Meryl Streep President Orlean Cate Blanchett Brie Evantee Rob Morgan Dr. Teddy Oglethorpe Jonah Hill Jason Orlean Mark Rylance Peter Isherwell Tyler Perry Jack Bremmer Timothée Chalamet Yule Ron Perlman Benedict Drask Ariana Grande Riley Bina Kid Cudi DJ Chello Himesh Patel Phillip Melanie Lynskey June Mindy Michael Chiklis Dan Pawketty Tomer Sisley Adul Grelio Paul Guilfoyle General Themes Robert Joy Congressman Tenant Jack Alberts Oliver Lance A. Williams Daniel Shimali de Silva Nisha Hettienne Park Dr. Calder Rafael Silva Nasa Scientist Lonnie Farmer Old Aide #1 Rena Maliszewski Anchor Reporting On Colon Conor Sweeney Marshall Mindy Ross Partridge Keith Ollens Liev Schreiber Bash Narrator (voice) Samsara Yett Isherwell Child Aide Meara Mahoney Gross Isherwell Child Aide Staci Roberts Linda Dicalio Chris Everett Chief Editor Paula Woods Annette Miller Mrs. Tanken Stephen Thorne Benjamin Natalie Rebenkoff Talent PA Gary Tanguay News Anchor #2 Georgia Lyman Groomer Thalia Ben Sidell Stage Manager Therese Plaehn Autopsy Editor In Charge Omar Ghonim Damian Meghan Leathers Media Quant Sarah Silverman Sarah Benterman Richard Snee Senator Lerner Jon Glaser Meow Man Dorothy Dwyer Old Tough Lady Alvin Keith Harrison Telms Lizzie Short French Reporter Sujoy De Hindi Reporter Lewis D. Wheeler Mission Coordinator Steve Gagliastro Onlooker David J. Curtis Guy Kevin Craig West Secretary of State Rob Lévesque Secretary of Interior Dee Nelson Dr. Lisa Inez Rebecca Gibel Waitress Brian Faherty Guy from the Bar Celeste Oliva Nearby Diner Roman Mitichyan Rioting Patron Alex Huynh Rioting Patron Leonardo DiCaprio Dr. Randall Mindy Jennifer Lawrence Kate Dibiasky Meryl Streep President Orlean Cate Blanchett Brie Evantee Rob Morgan Dr. Teddy Oglethorpe Jonah Hill Jason Orlean Mark Rylance Peter Isherwell Tyler Perry Jack Bremmer Timothée Chalamet Yule Ron Perlman Benedict Drask Ariana Grande Riley Bina Kid Cudi DJ Chello Himesh Patel Phillip Melanie Lynskey June Mindy Michael Chiklis Dan Pawketty Tomer Sisley Adul Grelio Paul Guilfoyle General Themes Robert Joy Congressman Tenant Jack Alberts Oliver Lance A. Williams Daniel Shimali de Silva Nisha Hettienne Park Dr. Calder Rafael Silva Nasa Scientist Lonnie Farmer Old Aide #1 Rena Maliszewski Anchor Reporting On Colon Conor Sweeney Marshall Mindy Ross Partridge Keith Ollens Liev Schreiber Bash Narrator (voice) Samsara Yett Isherwell Child Aide Meara Mahoney Gross Isherwell Child Aide Staci Roberts Linda Dicalio Chris Everett Chief Editor Paula Woods Annette Miller Mrs. Tanken Stephen Thorne Benjamin Natalie Rebenkoff Talent PA Gary Tanguay News Anchor #2 Georgia Lyman Groomer Thalia Ben Sidell Stage Manager Therese Plaehn Autopsy Editor In Charge Omar Ghonim Damian Meghan Leathers Media Quant Sarah Silverman Sarah Benterman Richard Snee Senator Lerner Jon Glaser Meow Man Dorothy Dwyer Old Tough Lady Alvin Keith Harrison Telms Lizzie Short French Reporter Sujoy De Hindi Reporter Lewis D. Wheeler Mission Coordinator Steve Gagliastro Onlooker David J. Curtis Guy Kevin Craig West Secretary of State Rob Lévesque Secretary of Interior Dee Nelson Dr. Lisa Inez Rebecca Gibel Waitress Brian Faherty Guy from the Bar Celeste Oliva Nearby Diner Roman Mitichyan Rioting Patron Alex Huynh Rioting Patron Michael Jibrin Federal Agent Bill Mootos Federal Attorney Patti Tippo French President Caroline Bergwall Teen Girl Friend Nate Richman Stocky FBI Agent John Bucy Don't Look Up'er Patrick Michael Strange Just Look Up'er Bianca de la Garza Entertainment Journalist Lance Norris Loyal Supporter Frank Ridley Flight Director Ishaan Khatter Raghav Manavalan Zach Holmes #LaunchChallenge MeTuber (uncredited) Chris Evans Devin Peters (uncredited) Marissa Carpio Reporter with Big Hair (uncredited) Luan Gallagher Boy looking at the meteor. (Uncredited)