Leonardo DiCaprio Ernest Burkhart Robert De Niro William Hale Lily Gladstone Mollie Burkhart Jesse Plemons Tom White Tantoo Cardinal Lizzie Q John Lithgow Prosecutor Peter Leaward Brendan Fraser W.S. Hamilton Cara Jade Myers Anna JaNae Collins Reta Jillian Dion Minnie Jason Isbell Bill Smith William Belleau Henry Roan Louis Cancelmi Kelsie Morrison Scott Shepherd Byron Burkhart Tatanka Means John Wren Tommy Schultz Blackie Thompson Sturgill Simpson Henry Grammer Gary Basaraba Detective Burns Charlie Musselwhite Alvin Reynolds Pat Healy Agent John Burger Steve Witting Dr. James Shoun Steve Routman Dr. David Shoun Gene Jones Pitts Beatty Michael Abbott Jr. Agent Frank Smith J. C. MacKenzie Radio Announcer Jack White Radio Show Actor Larry Sellers Non-Hon-Zhin-Ga Barry Corbin Undertaker Turton Gabriel Casdorph Agent Joe Jones Samuel French Agent CJ Robinson Randy Houser Scott Mathis Eric Parkinson Deputy Marshal John Gibbs Osage at oil Discovery Katherine Willis Myrtie Hale Ben Hall Sara's Murderer Justin France Card Player Lucas Ross Wedding Band Joshua Close Horace Burkhart Lee Eddy Mrs. Mackie James Healy Jr. 2nd Insurance Man Mary Buss John Ramsey's wife Larry Fessenden Radio Voice (for Hale) Martin Scorsese Radio Show Producer John Shaw End Celebration Osage Singer