Scott Menville Megamind (voice) Mirchi Kiran Roxanne Ritchi (voice) Justin Jarzombek OI' Chum (voice) Nitin Mehta Keiko Morita (voice) Laura Post Lady Doppler (voice) Maya Tuttle Lord Nighty-Knight (voice) Brian Gleeson Pierre Pressure (voice) Chrissy Metz Behemoth (voice) Izaac Wang Mel / Mr. Donut / TV Announcer (voice) Emily Tuñon Machiavillain (voice) Matthew Senreich Christina Christo / Hostess (voice) Taraji P. Henson Eccentric Eddie (voice) Talon Warburton Polly 227 (voice) Adam Lambert Big King Fish (voice) Eric Fogel Red Snapper (voice) Niall Horan Mayor (voice) David Herman Additional Voices (voice) Lindsay Hartley Additional Voices (voice) Seth Numrich Additional Voices (voice)